Facile, green, and functional group-tolerant reductions of carboxylic acids…in water
| Autor: | Karthik Iyer, Chandler Nelson, Bruce Lipshutz |
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| Rok vydání: | 2022 |
| DOI: | 10.26434/chemrxiv-2022-c3013 |
| Popis: | Facile reductions of carboxylic acids to aldehydes or alcohols can be effected under mild conditions upon initial conversion to their corresponding S-2-pyridyl thioesters. Upon treatment with a commercially available and air-stable nickel pre-catalyst and silane as a stoichiometric reductant, aldehydes are formed in moderate to good yields. Alternatively, the 1-pot conversion of acids to their thioester derivatives can be followed by reduction to the alcohol upon treatment with sodium borohydride. A variety of starting materials ranging from highly functionalized acids to educts from the Merck Informer Library can be transformed using these green reaction media. |
| Databáze: | OpenAIRE |
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