ChemInform Abstract: New Asymmetric Synthesis of Dexecadotril and Ecadotril Starting from a Single Precursor

Autor:	Pierre Duhamel, Claude Gros, Jean-Charles Schwartz, Denis Danvy, Lucette Duhamel, Jeanne-Marie Lecomte, Jean-Christophe Plaquevent, Thierry Monteil
Rok vydání:	2010
Předmět:	chemistry.chemical_compound DEXECADOTRIL Chemistry Ecadotril Enantioselective synthesis Organic chemistry General Medicine Enantiomer Desymmetrization
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200127092
Popis:	We describe herein a method providing access to both enantiomers of 3-acetylthio-2-benzylpropionic acid via enzymatic desymmetrization of 2-benzyl-1,3-propanediol. These compounds are respectively the starting materials for the synthesis of ecadotril, and dexecadotril, which are powerful inhibitors of NEP (EC 3.4.24.11) and have been developed as therapeutic agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7a784365153de62b7f3da713b579cb47 https://doi.org/10.1002/chin.200127092 Zobrazit plný text záznamu Plný text