Preparation of Essential Oils Loaded Granule by Melt Granulation

Autor:	Toshio Murakami, Kenji Ukita
Rok vydání:	1994
Předmět:	Pharmacology High-shear mixer Chromatography Materials science Organic Chemistry Granule (cell biology) Pharmaceutical Science Polyethylene glycol Granulation chemistry.chemical_compound Chemical engineering chemistry Fluidized bed Drug Discovery PEG ratio Particle-size distribution Particle size
Zdroj:	Drug Development and Industrial Pharmacy. 20:981-992
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049409038345
Popis:	A comparative study on three granulation methods; melt granulation, fluidized bed granulation and wet granulation was performed to fabricate an essential oils loaded granule. The granule properties such as particle size distribution and the loading efficiency of anethole from fennel and cinnamaldehyde from cinnamon showed that the melt granulation in a high shear mixer was the most feasible method among the three methods.In melt granulation, the granule particle size was well controlled by polyethylene glycol 6000 (PEG) content of which the optimum value was found to De 20%. Impeller speed and massing time in high shear mixer had small contribution to the particle growth when PEG content was optimized, while PEG particle size had some effect. Finer PEG powder improved the uniformity of granule size. Moreover, the cooling method of the hot mass affected the final granule properties significantly. The cooling with a fluid bed dryer was the best method.Both of the retention rates of anethole and cinn...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7a726895df5ead6ae811cd3e47bd2a20 https://doi.org/10.3109/03639049409038345 Zobrazit plný text záznamu