Synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes containing a chiral tetradentate ligand
| Autor: | Chuanzhu Gao, Liu Qinghua, Bai Linkui, Yunxu Qian, Linxiang Cai, Bo Yang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
A549 cell
010405 organic chemistry Chemistry Stereochemistry In vitro cytotoxicity chemistry.chemical_element 010402 general chemistry 01 natural sciences Carboplatin 0104 chemical sciences chemistry.chemical_compound Cell culture Materials Chemistry Physical and Theoretical Chemistry Tetradentate ligand Methylene Platinum Cytotoxicity |
| Zdroj: | Journal of Coordination Chemistry. 70:3759-3768 |
| ISSN: | 1029-0389 0095-8972 |
| DOI: | 10.1080/00958972.2017.1398822 |
| Popis: | A series of novel dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R,1′R,2R,2′R)-N1,N1′-(1,2-phenylenebis(methylene))dicyclohexane-1,2-diamine (HL), and mono-carboxylic acid derivatives as ligands have been designed, synthesized, and characterized. In vitro cytotoxicity evaluation of synthesized complexes against human HepG-2, A549, HCT-116, and MCF-7 cancer cell lines has been conducted by MTT assays. All compounds showed antitumor activity to HepG-2 and HCT-116 cell lines. Compound L2 exhibited better cytotoxicity than that of carboplatin against HepG-2 and A549 cell lines and also showed comparable activity against HCT-116 cell line. |
| Databáze: | OpenAIRE |
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