ChemInform Abstract: Copper-Catalyzed Cascade Substitution/Cyclization of N-Isocyanates: A Synthesis of 1-Aminobenzimidazolones

Autor:	Howard Alper, Andre M. Beauchemin, Jing An
Rok vydání:	2016
Předmět:	Cascade reaction Cascade Chemistry Substitution (logic) Polymer chemistry Copper catalyzed General Medicine
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201648142
Popis:	A copper-catalyzed cascade reaction of in situ generated nitrogen-substituted isocyanates (N-isocyanates) and 2-iodoanilines has been developed. The cascade relies on the base-catalyzed substitution of masked N-isocyanates, followed by Cu(I)-catalyzed coupling to afford a variety of 1-aminobenzimidazolones in moderate to excellent yields. This is the first example of a transition-metal-catalyzed cascade reaction involving N-isocyanate intermediates.
Databáze:	OpenAIRE
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