| Autor: |
Aida Sadikh Badiane, Jules F. Gomis, Aita Sene, Ibrahima Ndiaye, Daniel J. Park, Bronwyn MacInnis, Amadou Moctar Mbaye, Ngayo Sy, Katherine J. Siddle, Tolla Ndiaye, Younouss Diedhiou, Daouda Ndiaye, Awa B. Deme, Pardis C. Sabeti, Amy Gaye, Cheikh Ndiaye, Christopher Tomkins-Tinch, Mouhamad Sy, Alphonse B. Thiaw, Mouhamadou Falilou Ndiaye |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Dengue virus is a major and rapidly growing public health concern in tropic and subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue virus outbreak to date, covering several regions. However, little is known about the genetic diversity of dengue virus (DENV) in Senegal. Here we used molecular tools including metagenomic sequencing to identify 19 previously undetected dengue virus cases from the city of Thiès and assemble 17 complete virus genomes. DENV3 was the most frequent serotype; 11 sequences (65%) were DENV3, 4 sequences were DENV2 and 2 were DENV1. Sequences were closest to recent sequences from West Africa, suggesting ongoing local circulation of viral populations; however, detailed inference is limited by the scarcity of available genomic data. We did not find clear associations with reported clinical signs or symptoms, highlighting the importance of testing for diagnosing febrile diseases. Overall, these findings expand the known range of DENV in Senegal, and underscore the need for better genomic characterization of DENV in West Africa. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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