Oxygen Microsensor Array to Study Spatial Efficacy of Photodynamic Therapy in Vitro
| Autor: | Gerald Urban, Julia Marzioch, Jochen Kieninger, Andreas Weltin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Chemistry
Cellular respiration medicine.medical_treatment 010401 analytical chemistry Photodynamic therapy 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Electrochemical gas sensor Sensor array In vivo Cell culture Cancer cell medicine 0210 nano-technology Oxygen sensor Biomedical engineering |
| Zdroj: | 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). |
| Popis: | We present a cell culture monitoring platform to study effects of photodynamic therapy (PDT) on cancer cells. For the first time, it was possible to observe differences in cellular respiration at the transition between treated and untreated tumor cells in the same culture. Therewith more realistic in vitro studies of treatment efficiency and edge effects during PDT are possible. This resembles the spatially limited exposure in the in vivo situation. The sensor platform comprises an optically transparent microsensor chip with an integrated array of electrochemical oxygen microsensors and a LED light source for the photodynamic treatment. |
| Databáze: | OpenAIRE |
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