The Anti-Tumor Effects of Oenothera odorata Extract Are Mediated by Inhibition of Glycolysis and Cellular Respiration in Cancer Cells
| Autor: | Un-Hwan Ha, Sung-Jo Kim, Hyung Won Ryu, Won Jun Kim, Hyun Sik Jun, Eunmi Hwang, Jung-Hoon Lee, Park Sang Hyuk, Hyun-Jae Jang, Yeji Lee |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research 030109 nutrition & dietetics Nutrition and Dietetics Cell division biology Cellular respiration Cell growth Chemistry Medicine (miscellaneous) Oenothera odorata Pharmacology biology.organism_classification In vitro 03 medical and health sciences 0302 clinical medicine Oncology In vivo 030220 oncology & carcinogenesis Cancer cell Glycolysis |
| Zdroj: | Nutrition and Cancer. 73:2078-2088 |
| ISSN: | 1532-7914 0163-5581 |
| DOI: | 10.1080/01635581.2020.1824000 |
| Popis: | Cancer is caused by uncontrolled cell division and is a leading cause of mortality worldwide. Oenothera odorata (O. odorata) extract is used in herbal medicine to inhibit inflammation, but its potential anti-tumor properties have not been fully evaluated. Here, we demonstrated that O. odorata extract inhibits the proliferation of lung adenocarcinoma and melanoma cell lines In Vitro, and also inhibits the growth of melanoma cells In Vivo. After partitioning the extract with n-hexane, chloroform, ethyl acetate, and n-butanol, it was found that the butanol-soluble (OOB) and water-soluble (OOW) fractions of O. odorata extract are effective at inhibiting tumor cell growth In Vivo although OOW is more effective than OOB. Interestingly, these fractions did not inhibit the growth of non-cancerous cells. The anti-proliferative effects of the OOW fraction were found to be mediated by inhibition of glycolysis and cellular respiration. UPLC of both fractions showed two major common peaks, which were predicted to be hydrolyzable tannin-related compounds. Taken together, these data suggest that O. odorata extract has anti-tumor properties, and the molecular mechanism involves metabolic alterations and inhibition of cell proliferation. O. odorata extract therefore holds promise as a novel natural product for the treatment of cancer. |
| Databáze: | OpenAIRE |
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