Highly selective directed hydrogenation of enantiopure 4-( tert -butoxycarbonylamino)cyclopent-1-enecarboxylic acid methyl esters

Autor:	David A. Chaplin, Nadine Derrien, Raymond McCague, Michael C. Lloyd, Stephen Taylor, Mark E. B. Smith
Rok vydání:	2001
Předmět:	chemistry.chemical_compound Enantiopure drug chemistry Yield (chemistry) Organic Chemistry Drug Discovery Diastereomer Organic chemistry Highly selective DuPhos Biochemistry
Zdroj:	Tetrahedron Letters. 42:1347-1350
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)02210-3
Popis:	The use of both N-tert-butoxycarbonylamino- and hydroxyl-directed hydrogenation methodology to yield essentially single diastereomers of 3-(tert-butoxycarbonylamino)-4-hydroxycyclopentanecarboxylic acid methyl esters and 3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid methyl esters is described. These results incorporate the first reported carbamate-directed hydrogenations of functionalised cyclopentenes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7a545268cb67606b0df7c53031a0e314 https://doi.org/10.1016/s0040-4039(00)02210-3 Zobrazit plný text záznamu Full Text from ScienceDirect