Facile chelation-controlled reductive opening of methoxybenzylidene acetals with Bu3SnH and MgBr2. Regioselective protection strategy as MPM ethers

Autor:	Hiroo Dei, Osamu Yonemitsu, Megumi Yamauchi, Shin-ichi Kusaka, Bao‐Zhong Zheng, Katsuya Matsui
Rok vydání:	2000
Předmět:	Tedanolide chemistry.chemical_compound Chemistry Stereochemistry Reductive cleavage Organic Chemistry Drug Discovery Magnesium bromide Regioselectivity Chelation Protecting group Biochemistry Medicinal chemistry
Zdroj:	Tetrahedron Letters. 41:6441-6445
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)01017-0
Popis:	A mild and efficient regioselective reductive opening of methoxybenzylidene acetals using a combination of Bu 3 SnH and MgBr 2 ·OEt 2 , mainly via five-membered chelation intermediates is described. This reaction was applied to synthetic intermediates of myriaporon and tedanolide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7a5089b8eb1af8386e58d06116810aab https://doi.org/10.1016/s0040-4039(00)01017-0 Zobrazit plný text záznamu Full Text from ScienceDirect