Cubic POSS engineering of photosensitizer-doped semiconducting polymer nanoparticles for enhanced fluorescence imaging and amplified photodynamic therapy
| Autor: | Lianhui Wang, Peng Su, Yu Xu, Tianqi Liu, Xue Zhai, Biqing Bao, Bingbing Gu, Luyao Zhou |
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| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification Fluorescence-lifetime imaging microscopy Materials science Polymers and Plastics Organic Chemistry technology industry and agriculture Nanoparticle Quantum yield Bioengineering Polymer Photochemistry Biochemistry Fluorescence Silsesquioxane chemistry.chemical_compound chemistry lipids (amino acids peptides and proteins) Photosensitizer human activities Alkyl |
| Zdroj: | Polymer Chemistry. 11:7035-7041 |
| ISSN: | 1759-9962 1759-9954 |
| DOI: | 10.1039/d0py01199a |
| Popis: | Herein, we demonstrate photosensitizer-doped semiconducting polymer nanoparticles (SPNs) with simultaneous enhanced fluorescence brightness and amplified photodynamic performance through the simple introduction of a cubic polyhedral oligomeric silsesquioxane (POSS) structure and alkyl chains. Compared to semiconducting polymer nanoparticles that are doped with THPP (THPP-doped PFO NPs and THPP-doped PFBT NPs), PorPOSSC12-doped SPNs exhibited roughly 7.2 times and 3.2 times higher fluorescence quantum yield for PorPOSSC12-doped PFO NPs and the PorPOSSC12-doped PFBT NPs, respectively. Moreover, the stability of these particles could be improved effectively by the interaction of POSS and the long alkyl chains in the photosensitizer with the polymer backbones of the nanoparticles. In vitro experiments also proved that these PorPOSSC12-doped semiconducting polymer nanoparticles showed bright fluorescence imaging and enhanced photodynamic effects. This strategy is expected to be applicable to a broad range of semiconducting polymers for the development of SPN-based photosensitizer bright fluorescence emission, efficient PDT ability, and improved colloidal stability. |
| Databáze: | OpenAIRE |
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