Effects of Cimetidine and Ranitidine on Hepatic Monooxygenase Activity in Humans

Autor:	Mitsuyoshi Goto, Shinji Nakajima, Satoshi Yamada, Chieko Ohnishp, Hajime Yamashina
Rok vydání:	1983
Předmět:	Pharmacology medicine.medical_specialty biology Chemistry Urine Drug interaction Enzyme assay Ranitidine Endocrinology Enzyme system Internal medicine medicine biology.protein Ingestion Pharmacology (medical) Monooxygenase activity Cimetidine medicine.drug
Zdroj:	Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 14:605-611
ISSN:	1882-8272 0388-1601
DOI:	10.3999/jscpt.14.605
Popis:	The effect of cimetidine and ranitidine administration on hepatic drug-metabolizing enzyme activity was investigated in 7 healthy volunteers using the ratio of 6-hydroxycortisol (6-OHF) to total 17-hydroxycorticosteroids (17-OHCS) in 24 hr urine as an index of the hepatic P-450-dependent enzyme system. Although the ratio of 6-OHF to 17-OHCS in different individuals varied from 0.043 to 0.074, the values obtained in three trials at one month intervals are highly reproducible within the same subjects. In contrast with very little effect of ranitidine ingestion at a 150 mg dose on hepatic P-450 systems, oral cimetidine administration at a dose of 200 mg four times a day immediately reduced the ratio from 0.058±0.008 to 0.045±0.009 (mean±S. D., P
Databáze:	OpenAIRE
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