Synthesis of one-, two- and three-ring macrocyclic, bifunctional compounds for use in radiolabelling monoclonal antibodies

Autor:	Suzanne V. Smith, Martalena Rami, Leonard F. Lindoy, Ying Dong, J.Gerald Wilson
Rok vydání:	2005
Předmět:	chemistry.chemical_compound Stereochemistry Chemistry medicine.drug_class Organic Chemistry medicine Dioxocyclam Monoclonal antibody Ring (chemistry) Bifunctional Combinatorial chemistry Alternative strategy
Zdroj:	Journal of Heterocyclic Chemistry. 42:77-83
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570420111
Popis:	The synthesis of new linked bis- and tris-ring tetraazamacrocyclic (bifunctional) reagents for use in an alternative strategy for radiolabelling antibodies is described. For comparison with the above systems, a new single ring bifunctional system incorporating a dioxocyclam ring is also reported.
Databáze:	OpenAIRE
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