GROWTH HORMONE (GH) TREATMENT OF CHILDREN WITH CHRONIC RENAL FAILURE (CRF) AFTER RENAL TRANSPLANTATION (Tx)
| Autor: | Castellano Marisa, Mendilarharzu Fernando, Belgorosky Alicia, Rivarola Marco, Turconi Amalia |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.medical_treatment Renal function Growth hormone Transplantation Endocrinology Sex hormone-binding globulin Internal medicine Pediatrics Perinatology and Child Health medicine biology.protein Gh treatment Chronic renal failure Analysis of variance business Dialysis |
| Zdroj: | Pediatric Research. 36:823-823 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199412000-00025 |
| Popis: | Children with CRF grow poorly and, frequently, neither dialysis nor Tx improve growth. It has been proposed that these children have target organ resistance to the effects fo GH/IGF-I which could be overcome by supraphysiological doses of GH. Our objective was to evaluate growth response and renal function after GH treatment (1 IU/Kg. week) in patients with CRF after Tx. Seven patients (5 prepubertal and 2 pubertal children) were studied: mean ± SD chronological age (A) 12.2±3.25 years (y), bone A 8.47±3.94 y, height SDS −3.82±1.44 and post Tx time 1.99±2.16 y. All patients had normal serum T4 and T3 levels and GH responses to pharmacological tests (> 7 ng/ml). Mean GH treatment time was 7.0±3.46 moths. Parameters of biological actions of GH (growth velocity : GV, serum levels of SHBG and IGF-1) and of renal function (Cr cl) were evaluated before and after treatment. Findings were as follows: a significative increment in GV (from 2.46±0.63 to 7.42±1.68 cm/y, p< 0.001, ANOVA), similar CrCI (96.2±12.9 and 100.6±25.8 ml/min. 1.73m ), a significant decrement in serum SHBG (from 75.9±32.4 to 55.5±31.5 nmol/L, p |
| Databáze: | OpenAIRE |
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