Ductal Carcinoma in Situ of the Breast

Autor: Michael D. Lagios, Melvin J. Silverstein, Melinda S. Epstein
Rok vydání: 2018
Předmět:
Popis: Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous group of lesions with diverse malignant potential and a range of treatment options. It is the most rapidly growing subgroup in the breast cancer family of disease with more than 60,000 new cases diagnosed in the United States during 2016. More than 90% of newly diagnosed DCIS are nonpalpable and discovered mammographically. It is now well appreciated that DCIS is a stage in the neoplastic continuum in which the majority of biological alterations required for the development of invasive breast cancer are already present. The fact that DCIS was rarely observed as the sole component of a biopsy before 1980 and that it is associated with invasive breast cancer approximately 85% of the time, clearly indicate that DCIS is the precursor lesion for most invasive breast tumors. However, not all DCIS lesions have sufficient time or all the genetic alterations required for progression to invasive disease. As our understanding of DCIS has evolved, so has its treatment. Clinical research has focused on the identification of prognostic and biological factors that strongly influence treatment selection while new surgical and radiologic techniques have developed to accommodate these new therapy options. This chapter reviews each of these subjects to provide the reader a workable framework on which to evaluate DCIS treatment decisions for a specific patient.
Databáze: OpenAIRE
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