| Autor: |
Chiharu Ishii, Kyoji Hioki, Mamoru Ito, Tomoyuki Ogura, Masahiro Sugimoto, Naoko Tachibana, Ryouko Nozu, Tomoyoshi Soga, Masami Ueno, Kenta Suzuki, Masaru Tomita, Shinnosuke Murakami, Hiroshi Ohno, Yumiko Nakanishi, Akiyoshi Hirayama, Shinji Fukuda, Yuyo Ka, Tamotsu Kato, Ayumi Ito |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Background: Aging is a progressive decline of cellular functions that ultimately affects whole-body homeostasis. Alterations in the gut microbiota associated with aging have been reported, however the molecular basis of the relationships between host aging and the gut microbiota is poorly understood.Result: By using longitudinal microbiome and metabolome characterization, we show that the aging-related alterations in the intestinal environment lead to gut dysbiosis with a potential to induce obesity in mice. In middle-age mice, we observed more than a 2-fold increase in fecal carbohydrates derived from dietary polysaccharides and a significant reduction of gut microbial diversity resembling the microbiota characteristic of obese mice. Consistently, fecal microbiota transplantation from middle-age specific pathogen-free (SPF) mice into young germ-free (GF) mice resulted in increased weight gain and impaired glucose tolerance.Conclusion: Our findings provide new insights into the relationships between host aging and gut dysbiosis and may contribute to the development of a possible solution to aging-related obesity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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