Autor: Angel L.M. de Francisco, Julio G. Cotorruelo, Juan Carlos Ruiz, Emilio Rodrigo, Manuel Arias, Gema Fernández-Fresnedo, M Heras, Celestino Piñera, J.A Zubimendi
Rok vydání: 2002
Předmět:
Zdroj: International Urology and Nephrology. 33:173-177
ISSN: 0301-1623
DOI: 10.1023/a:1014428817740
Popis: Background: In recent years acceptance ofdiabetic patients for renal replacement therapyhas increased. Renal transplantation for Type Idiabetic patients is widely accepted but theappropriate treatment for Type II diabeticpatients is still a matter of dispute. Ourstudy was done to determine whether the age ofType II diabetic patients constituted anadditional risk factor.Methods: We analyzed the outcome of renaltransplantation in 56 diabetic patients, 31Type I and 25 Type II diabetics (we excludedany who had combined kidney-pancreastransplants). We compared them with 51non-diabetic patients who were transplantedbecause of end-stage renal failure due tonephrosclerosis and age-matched to type IIdiabetic patients. We assessed the one- andthree-year patient and graft survival, thequality of renal function, the maincomplications and causes of mortality.Results: The overall one- and three-yearpatient survival was 69% and 60% in Type IIpatients; 73% and 69% in Type I diabetespatients and 88% and 80% in patients withnephrosclerosis. The overall one- andthree-year actuarial graft survival was 50%and 38% in patients with Type II disease and58% and 50% in Type I diabetes, and 76% and64% in nephrosclerosis. The main cause ofgraft loss in all groups was death (withfunctioning kidney) due to infections andcardiovascular complications.Conclusions: Diabetes itself is the mostimportant variable in patients who have poorresults after kidney transplantation.Increasing age increases slightly the risk forpoor graft and patient survival. Both groups ofdiabetic patients have poorer results thancontrols but in this comparison age was anindependent factor.
Databáze: OpenAIRE
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