A review of the outcomes of patients with anal cancer enrolled in the Hurley Cancer Registry: 1987-2004

Autor: A. Akl, S. Subramonia Iyer
Rok vydání: 2009
Předmět:
Zdroj: Journal of Clinical Oncology. 27:e15131-e15131
ISSN: 1527-7755
0732-183X
DOI: 10.1200/jco.2009.27.15_suppl.e15131
Popis: e15131 Background: This paper describes the outcomes of patients with anal cancer enrolled in the Hurley Cancer Registry. Methods: Retrospective registry and chart review study. The Hurley cancer registry was searched using diagnosis codes for anal cancer. The records retrieved, were reviewed for demographic and pathologic details,cancer recurrence, and vital status at last follow up. Relative survival was calculated for the patient cohort. Results: Over a period of 18 years (1987 - 2004), there were 36 patients enrolled in the registry, with a diagnosis of anal cancer. There were 18 males and 18 females. Mean age at diagnosis was 59.3 (SD 17.6) years for males, and 64.6 (SD 13.8) years for females. Squamous cell cancers were the most common: 27 / 36 (75%). The median survival of these 36 patients was 6 years. The median disease free survival was 5.3 years. Five patients (14%) developed recurrent disease during follow up, after a median of 1.8 years (range: 0.67- 4.2 years). Four of these patients had local recurrence only. One patient had local, regional recurrence with distant metastases. Three of the five (60%) recurrent cancers were associated with HIV infection. For all patients without recurrence, the median survival is 7.1 years. Relative survival is the observed survival adjusted for expected mortality. The expected survival probabilities for 3-yr and 5-yr intervals were calculated using the age, sex and race- matched survivorship information U.S. population life tables for 1989–91 and 1999–2001. Cumulative survival functions for the cohort were derived for the time points of 3-yrs and 5-yrs after diagnosis. The relative survival for the cohort was 84.6% at 3 years and 79.8% at the end of five years of follow up. These results appear superior when compared to the overall 5-year relative survival rate for 1996–2004 from 17 SEER geographic areas, which was 66.5%. Conclusions: Among patients in the Hurley Cancer Registry, 1. Squamous cell carcinoma is the commonest (75%) anal cancer. 2. The risk of recurrence of anal cancer was 14% over 6-years, and 80% of recurrence was localised to the anal canal. 3. The relative survival for the cohort was 79.8% at the end of five years of follow up. This was 78.9% for the subgroup of patients without recurrence, and 86.1% for the subgroup with recurrent disease. No significant financial relationships to disclose.
Databáze: OpenAIRE
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