ASSESSMENT OF DRUG DRUG INTERACTIONS AND ITS ASSOCIATED FACTORS IN PATIENTS RECEIVING SECOND-LINE ANTITUBERCULAR DRUGS (MDR TB/XDR TB) IN A TERTIARY CARE HOSPITAL IN EASTERN INDIA
| Autor: | Srikanta Mohanty, Shweta Supriya Pradhan, Geetanjali Panda, P. Ansuman Abhisek, Priti Das |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
medicine.medical_specialty business.industry media_common.quotation_subject Biomedical Engineering Medicine (miscellaneous) Health Informatics Tertiary care hospital Eastern india Biomaterials Regimen Second line Pharmacodynamics Internal medicine Medicine Observational study Medical prescription business media_common |
| Zdroj: | International Journal of Medical Engineering and Informatics. 13:1 |
| ISSN: | 1755-0661 1755-0653 |
| DOI: | 10.1504/ijmei.2021.10023396 |
| Popis: | This was a prospective, observational study conducted to assess prevalence of different spectrum of DDIs in MR/XDR TB patients by analyzing 42 prescriptions. DDIs were analysed by softwares like Lexicomp, Micromedex, and Drugs.com, Medscape.com. Only interactions of major/moderate severity were included in the potential DDIs analysis. Quantitative assessments were compared using one way ANOVA. Qualitative assessment of software was done manually by mere observation. Patients received 12.52 (±4.04) drugs during their total treatment period. Among 467 interactions observed, 34.04% were major, 50.10% moderate. All the patients had at least one potential DDI and 92.85% were exposed to at least one major potential DDI. Among the 'risk rating avoid combinations' (X) were 7.28%, 'modify regimen' (D) were 15.04%. Most DDIs were of moderate severity (50.10%) and the possible mechanism of DDI found was of pharmacodynamic in nature (49.76%). This study assists in understanding the utility of computer software-based programs to assess potential DDIs and the factors associated with them. |
| Databáze: | OpenAIRE |
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