Nonspecific Lymphocytic Myocarditis in Baboons Is Associated with Trypanosoma cruzi Infection
| Autor: | Michaelle L. Hohmann, Márcia Cristina Ribeiro Andrade, Rodolfo Guardado-Mendoza, John L. VandeBerg, Gene B. Hubbard, Edward J. Dick, Cheryl D. DiCarlo, Diana C. P. Mejido |
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| Rok vydání: | 2009 |
| Předmět: |
Chagas disease
medicine.medical_specialty Pathology Myocarditis biology Clinical pathology viruses social sciences biology.organism_classification medicine.disease Serology Infectious Diseases Virology Monkey Diseases biology.animal parasitic diseases Immunology medicine Parasitology Trypanosoma cruzi Trypanosomiasis geographic locations health care economics and organizations Baboon |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 81:235-239 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Non-specific lymphocytic myocarditis (NLM) is frequently observed in baboons within the endemic range of Trypanosoma cruzi. We sought to determine whether T. cruzi infection is a cause of baboon NLM. We evaluated serial histologic sections of cardiac muscle, blood cultures, immunohistochemistry, serology, polymerase chain reaction, and clinical pathology from 31 baboons with NLM to determine whether T. cruzi infection is associated with NLM. Eleven baboons with no evidence of T. cruzi infection by serology and no NLM were used as controls. Seropositivity for T. cruzi was 45% in baboons with NLM compared with a 2–3% colony prevalence. NLM lesion severity was significantly higher in seropositive than seronegative baboons with NLM. NLM was significantly more common in older baboons. No statistical association between NLM and sex, weight, or clinical pathology was found. These results suggest an association between NLM and T. cruzi infection in the baboon. |
| Databáze: | OpenAIRE |
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