What Can the NZB/W Mice Teach us about the Treatment of SLE with Ciclosporin?

Autor:	J. F. Borel, H. C. Gunn, Bernhard Ryffel, P. C. Hiestand
Rok vydání:	1985
Předmět:	Proteinuria biology business.industry Glomerulonephritis Disease medicine.disease Ciclosporin Immune complex immune system diseases Immunology medicine biology.protein Chronic renal failure medicine.symptom Antibody skin and connective tissue diseases business medicine.drug
Zdroj:	Ciclosporin in Autoimmune Diseases ISBN: 9783642706097
Popis:	Female NZB/W hybrid mice spontaneously develop a disease that resembles human systemic lupus erythematosus (SLE) [1]. Briefly, by 4 months of age these mice develop anti-DNA antibodies; by 10 months of age they develop anti-red-blood cell (RBC) antibodies and a systemic immune complex (IC) disease with glomerulonephritis (GN) and proteinuria, and by 12 months of age they have a predictable course to chronic renal failure with about 50% mortality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::79f9a210bcd442ab9ed36974428a1b0d https://doi.org/10.1007/978-3-642-70607-3_65 Zobrazit plný text záznamu