New type of biosensor based on magnetic nanoparticle detection

Autor: T. I. Ksenevich, Petr Mikhailovich Vetoshko, Petr I. Nikitin
Rok vydání: 2007
Předmět:
Zdroj: Journal of Magnetism and Magnetic Materials. 311:445-449
ISSN: 0304-8853
Popis: A new type of biosensor has been developed based on detection of nanosized superparamagnetic particles that serve as labels in bioreactions. The method is based on non-linear magnetic material detection by a magnetic field having components at two frequencies f 1 and f 2 . The response is measured at the combinatorial frequencies f i = mf 1 + nf 2 , where m and n are integers, e.g., f i = f 1 ±2 f 2 . Several highly sensitive readers of superparamagnetic particles have been designed and used for development of various formats of immunoassays, including those compatible with immunoconcentration and magnetic enrichment of antigens.
Databáze: OpenAIRE