Fabrication of pH/H2O2-responsive polyhedral oligomeric silsesquioxane self-assembled fluorescent vesicles for enhanced in vivo anti-tumor efficacy
| Autor: | Shuxian Ren, Guiyang Zhang, Wanling Shi, Weizhi Li, Xudong Jia |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Nanomedicine. 17:671-682 |
| ISSN: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm-2021-0302 |
| Popis: | Aim: The rational design of a fluorescence imaging-guided, highly efficient multiresponsive delivery system is important for improving drug delivery efficiency. Materials and methods: Herein, pH/H2O2-responsive polyhedral oligomeric silsesquioxane (POSS) molecule functionalized 4-(phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)amino)benzaldehyde (OTB) copolymer (PEG-POSS-OTB) was synthesized to encapsulate doxorubicin (DOX) for precise drug delivery. Results: The self-assembly fluorescent vesicles exhibited excellent pH/H2O2-responsive drug release properties under physiological conditions and efficient drug-targeting ability. In vitro, compared with the DOX group, PEG-POSS-OTB fluorescent vesicles exhibited improved drug delivery and reduced toxicity. Importantly, we performed a proof-of-concept study demonstrating that PEG-POSS-OTB fluorescent vesicles were a high-efficiency nanoassembly drug-delivery platform for improving drug delivery efficiency. In vivo studies demonstrated that PEG-POSS-OTB vesicles with enhanced stability could be used in targeted drug delivery and controlled intelligent release. |
| Databáze: | OpenAIRE |
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