Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

Autor:	Stefano Crotti, Marta Tontini, Elisa Danieli, Roberto Adamo, Doug Quinn, Francesco Berti, Sonia Ortiz, Jing Zhou, Kirk Clark, Giulia Brogioni, Bing Wang, Qi-Ying Hu, Huili Zhai, Guangxiang Wu, Martin Allan
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Glycan biology Glycoconjugate Sequence (biology) General Chemistry Laminarin chemistry.chemical_compound chemistry Biochemistry biology.protein Click chemistry Tyrosine Antibody Glucan
Zdroj:	Chemical Science. 4:3827
ISSN:	2041-6539 2041-6520
Popis:	An anti-candidiasis glycoconjugate vaccine was prepared via a tyrosine-selective alkynylation and a click chemistry mediated glycoconjugation sequence. It features a well-defined glycan, protein carrier, and connectivity. The construct, although with significantly lower carbohydrate loading and a shorter β-(1,3) glucan chain than the well-established anti-candidiasis vaccine derived from the random conjugation of laminarin at lysines, elicited a comparable level of specific IgG antibodies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::79f116ad0510d4e43d9e52a76844a1f0 https://doi.org/10.1039/c3sc51694f Zobrazit plný text záznamu