Effects of Tandospirone Citrate and Oxazolam on Pharmacokinetics of Valproic Acid Following Oral Administration of Sodium Valproate to Rats

Autor:	Hiromasa Kameya, Nobuo Hokama, Norio Hobara, Matao Sakanashi, Susumu Ohshiro, Narumi Hobara
Rok vydání:	2007
Předmět:	Benzodiazepine Valproic Acid medicine.drug_class Pharmacology Tandospirone chemistry.chemical_compound Pharmacokinetics chemistry Oral administration medicine Convulsant lipids (amino acids peptides and proteins) Oxazolam Citric acid medicine.drug
Zdroj:	Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 33:496-501
ISSN:	1882-1499 1346-342X
DOI:	10.5649/jjphcs.33.496
Popis:	The drug interactions between tandospirone citrate,a non-benzodiazepine antianxiety drug,and oxazolam,a minor benzodiazepine tranquilizer and antianxiety agent,and valpronic acid (VPA),an anti-convulsant,were studied in rats.When tandospirone citrate or citric acid was administered orally immediately following oral administration (p.o.) of sodium valproate (VPA-Na),the plasma VPA levels were significantly lower than those in the control.In addition,pharmacokinetic parameters such as plasma VPA concentration and area under the plasma concentration-time curve up to 3 hr (AUC) were significantly decreased.However,when tandospirone citrate was administered intraperitonally,or both it and oxazolam were administered orally with VPA-Na,the VPA pharmacokinetic parameters were unchanged.These results suggest that decreases in plasma VPA concentrations (including those for AUC) may be due to a reduction in VPA-Na adsorption from the intestinal tract due to tandospirone citrate.
Databáze:	OpenAIRE
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