Deuteron and phosphorus-31 NMR study of the interaction of general anesthetics with phosphatidylcholine membranes

Autor:	Bruce J. Forrest, Jairajh Mattai
Rok vydání:	1985
Předmět:	Liposome General anesthetics Chemistry Bilayer Chloral hydrate Synthetic membrane Dihedral angle Biochemistry chemistry.chemical_compound Membrane Phosphatidylcholine medicine Biophysics Organic chemistry medicine.drug
Zdroj:	Biochemistry. 24:7148-7153
ISSN:	1520-4995 0006-2960
DOI:	10.1021/bi00346a019
Popis:	The effect of the general anesthetics alpha-chloralose and chloral hydrate as well as the nonanesthetic beta-chloralose on the order of phosphatidylcholine and phosphatidylcholine-cholesterol liposomes has been examined by 2H nuclear magnetic resonance. Chloral hydrate interacts with the hydrophilic head-group region, causing a change in the torsion angle of the C alpha-C beta bond. The membrane interior is also disordered by the presence of this agent. alpha-Chloralose, on the other hand, disorders only the central position of the membrane. beta-Chloralose produces little significant change in bilayer order.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::79ed3a4054ec358bc30b73116d7f1347 https://doi.org/10.1021/bi00346a019 Zobrazit plný text záznamu