| Autor: |
J. O’Nions, L. Muir, J. Zheng, C. Rees-Spear, A. Rosa, C. Earl, P. Cherepanov, R. Gupta, A. Khwaja, C. Jolly, L.E. McCoy |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.09.29.20202846 |
| Popis: |
The development of antibody responses to SARS-CoV-2 is an indicator of seroprevalence and may afford protection from infection. It has been presumed that antibody responses to SARS-CoV-2 will be impaired in patients with aggressive haematological malignancy (PHM) due to underlying immunological dysfunction caused by malignancy or systemic anti-cancer treatment (SACT), placing them at increased risk. Here we analysed longitudinal serum samples from ten hospitalised PHM with aggressive disease and on SACT, collected up to 103 days post-onset of COVID-19 symptoms. We found that the majority (8/9) of PHM with confirmed SARS-CoV-2 infection seroconverted and developed antibodies to the major SARS-CoV-2 antigens (S1 and N) with most (6/8) produced neutralising antibody responses. Furthermore, the dynamics of antibody responses were broadly similar to that reported for the general population, except for a possible delay to seroconversion. Our finding that PHM on SACT can make functional antibody responses to SARS-CoV-2 has important implications for patient management and serological monitoring of SARS-CoV-2 in high-risk groups. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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