Dynamical behavior of combinational immune boost against tumor

Autor: Mizuho Nagata, Shinji Nakaoka, Yutaro Furuta, Yasuhiro Takeuchi
Rok vydání: 2015
Předmět:
Zdroj: Japan Journal of Industrial and Applied Mathematics. 32:759-770
ISSN: 1868-937X
0916-7005
Popis: Recent clinical progresses indicate effectiveness of dendritic cell therapy against tumor. Targeting dendritic cells as a mean of enhancing tumor specific T cell responses requires efficient antigen presentation to boost adaptive immune responses. Exploration of tumor specific antigen is therefore the best practice for the development of novel immunotherapy against tumor. On the other hand, combinational enhancement of tumor specific immune response is a subsequent potential therapy on the basis of the discovery of tumor specific antigen. Although empirical applications of combinational immune boost such as dendritic boost of T cells or NKT cells are known, dynamical behaviors of immune response and tumor immune escape at the population level remain largely unknown. In the present paper, we construct a mathematical model representing dynamical behaviors of T cell tumor response under the support of dendritic cells. Mutual dependence of dendritic and T cells in activation and tumor elimination leads to bistability between tumor immune escape and immuno-suppressive states. Extensive numerical computations indicate the high opportunities of tumor immune escape despite the presence of high antigenic stimulation. These results can explain one of dynamical patterns of tumor immune escape.
Databáze: OpenAIRE
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