Sodium bis(2-methoxyethoxy)(1,1,1,3,3,3-hexafluoro-2-propoxy)aluminum hydride, a new stereoselective reducing agent in a carbacyclin synthesis

Autor:	Susumu Harashima, Shigeo Amemiya, Koichi Kojima, Osamu Oda
Rok vydání:	1991
Předmět:	Bicyclic molecule Chemistry Reducing agent Organic Chemistry Acetal Regioselectivity Biochemistry Medicinal chemistry chemistry.chemical_compound Drug Discovery Organic chemistry Moiety Stereoselectivity HOMO/LUMO Enone
Zdroj:	Tetrahedron. 47:2773-2784
ISSN:	0040-4020
Popis:	A new reducing agent ( 2j ) reduced the enone ( 4 ) to give 15( S )-allylic alcohol ( 5a ) with excellent regio- and stereoselectivity through a five membered ring transition state. Stereoselecrivity of this reaction will be explained based on the LUMO of the enone moiety. The resulting ( 5a ) was led to a carbacyclin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::79e8273c6818921e342145e7dc578919 https://doi.org/10.1016/s0040-4020(01)87084-8 Zobrazit plný text záznamu