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Objective: To compare the anti-hyperglycaemic effectiveness and safety of different anti-diabetic treatment regimens in fasting type 2 diabetic subjects during Ramadan. Methods: This was a prospective four-week study of 161 subjects with type 2 diabetes (HbA1c 6.5-8.5%) during Ramadan, at the Department of Endocrinology & Metabolism, Services Hospital, Lahore, Pakistan. Study participants were randomized into four treatment groups: lifestyle modification only (group 1: lifestyle), metformin monotherapy (group 2: Metformin), metformin and sulfonylurea (group 3: Met/SU) and metformin and DPP4 inhibitor (group 4: Met/Sita). Anthropometric and biochemical evaluation were done one week before onset of Ramadan and in the last week of Ramadan. 134 patients completed the study protocol and repeated measures ANOVA was used to compare the groupsfor change inclinical and laboratory parameters from pre-Ramadan baseline. Results: There was a significant decrease in mean blood glucose (mg/dL) and fructosamine(µmol/L)levels post-Ramadan in all treatment groups, with the greatest reduction seen in Met/Sita treatment group [(fructosamine -35.9, p |
