Synthesis and antiviral activity of 6-halo-1,2-naphthoquinones
Autor: | G. N. Pershin, I. S. Nikolaeva, A. N. Grinev, N. S. Bogdanova, V. V. Peters, G. Ya. Uretskaya, N. V. Arkhangel'skaya |
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Rok vydání: | 1978 |
Předmět: | |
Zdroj: | Pharmaceutical Chemistry Journal. 12:1005-1008 |
ISSN: | 1573-9031 0091-150X |
Popis: | In connection with the high antiviral activity of 6-bromo-l,2-naphthoquinone (bonaphrhone) [1-4], it was of interest to study the nature of the effect of the halogen substituent in the 6 position of 1,2-naphthoquinone on the direction and character of its antiviral activity. In the present work we have synthesized and studied the action of 6-fluoro-, 6chloro-, and 6-iodo-l,2-naphthoquinones on the influenza viruses A/PR/8/34 (HONI), A/England 42/72 (H3N2), and simple herpes virus of type I, strain I-C. Thereupon the activity of the latter was compared with the antiviral activity of bonaphthone. |
Databáze: | OpenAIRE |
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