Synthesis and antiviral activity of 6-halo-1,2-naphthoquinones

Autor:	G. N. Pershin, I. S. Nikolaeva, A. N. Grinev, N. S. Bogdanova, V. V. Peters, G. Ya. Uretskaya, N. V. Arkhangel'skaya
Rok vydání:	1978
Předmět:	Pharmacology chemistry.chemical_compound Herpes virus Stereochemistry Chemistry Drug Discovery Pharmacology toxicology Substituent
Zdroj:	Pharmaceutical Chemistry Journal. 12:1005-1008
ISSN:	1573-9031 0091-150X
Popis:	In connection with the high antiviral activity of 6-bromo-l,2-naphthoquinone (bonaphrhone) [1-4], it was of interest to study the nature of the effect of the halogen substituent in the 6 position of 1,2-naphthoquinone on the direction and character of its antiviral activity. In the present work we have synthesized and studied the action of 6-fluoro-, 6chloro-, and 6-iodo-l,2-naphthoquinones on the influenza viruses A/PR/8/34 (HONI), A/England 42/72 (H3N2), and simple herpes virus of type I, strain I-C. Thereupon the activity of the latter was compared with the antiviral activity of bonaphthone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::79d6b89d37aa71c570473c9af5beabbe https://doi.org/10.1007/bf00778055 Zobrazit plný text záznamu Full text from SpringerLink