The Antineoplastic Properties and Mechanism of Interaction of an Antioxidant, Sodium 2-Carboxy-2-(N-Aсetylamino)-3-(3,5-di-tert-Butyl-4-Hydroxyphenyl)Propionate, with Peptides in an Aqueous Environment According to the Data of the Calculation by Quantum Chemistry Methods
| Autor: | A. A. Albantova, E. M. Mil, V. N. Erokhin, A. A. Volod'kin, V. I. Binyukov |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Aqueous solution 010304 chemical physics Sodium medicine.medical_treatment Intraperitoneal injection Intermolecular force chemistry.chemical_element 010402 general chemistry 01 natural sciences Quantum chemistry Medicinal chemistry 0104 chemical sciences chemistry Apoptosis 0103 physical sciences medicine Propionate Physical and Theoretical Chemistry |
| Zdroj: | Russian Journal of Physical Chemistry B. 14:443-449 |
| ISSN: | 1990-7923 1990-7931 |
| DOI: | 10.1134/s1990793120030136 |
| Popis: | The antineoplastic properties of an antioxidant, sodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, are studied on an ascites tumor, Sarcoma 37, and on a solid tumor, Lewis carcinoma. A full suppression of Sarcoma 37 and an intensification of apoptosis (a decrease in the level of Bcl-2 antiapoptotic protein) in the cells of Lewis carcinoma are observed for intraperitoneal injection of the preparation. The structure of the complexes of sodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate with peptides is calculated using quantum chemistry. Quantitative data are obtained which characterize the intra- and intermolecular interactions of the above components in nanoassociates. |
| Databáze: | OpenAIRE |
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