The evidence for and against different modes of tumour cell extravasation in the lung: diapedesis, capillary destruction, necroptosis, and endothelialization
| Autor: | Katalin Dezso, Peter Nagy, Sándor Paku, Walter Klepetko, Mir Alireza Hoda, Andrew R. Reynolds, Viktoria Laszlo, József Tímár, Ferenc Rényi-Vámos, Balazs Dome |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Lung business.industry Mechanism (biology) Necroptosis Cell Cancer medicine.disease Extravasation Pathology and Forensic Medicine Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Medicine business Pathological |
| Zdroj: | The Journal of Pathology. 241:441-447 |
| ISSN: | 0022-3417 |
| DOI: | 10.1002/path.4855 |
| Popis: | The development of lung metastasis is a significant negative prognostic factor for cancer patients. The extravasation phase of lung metastasis involves interactions of tumour cells with the pulmonary endothelium. These interactions may have broad biological and medical significance, with potential clinical implications ranging from the discovery of lung metastasis biomarkers to the identification of targets for intervention in preventing lung metastases. Because of the potential significance, the mechanisms of tumour cell extravasation require cautious, systematic studies. Here, we discuss the literature pertaining to the proposed mechanisms of extravasation and critically compare a recently proposed mechanism (tumour cell-induced endothelial necroptosis) with the already described extravasation mechanisms in the lung. We also provide novel data that may help to explain the underlying physiological basis for endothelialization as a mechanism of tumour cell extravasation in the lung. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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