Estrogenic Flavonoids from Artemisia vulgaris L

Autor:	Camelia Maier, Richard A. Dixon, Angela R. Wood, Ha-Yull Chung, Sang-Jun Lee, Tom J. Mabry
Rok vydání:	1998
Předmět:	Homoeriodictyol food and beverages General Chemistry Eriodictyol Biology Chrysoeriol chemistry.chemical_compound chemistry Biochemistry Apigenin heterocyclic compounds General Agricultural and Biological Sciences Quercetin Kaempferol Luteolin Isorhamnetin
Zdroj:	Journal of Agricultural and Food Chemistry. 46:3325-3329
ISSN:	1520-5118 0021-8561
DOI:	10.1021/jf9801264
Popis:	The comprehensive quantitative analysis of the flavonoid chemistry of Artemisia vulgaris L., a plant used as an emmenagogue in traditional medicine, is presented in conjunction with an evaluation of its estrogenic activity. Twenty known flavonoids were isolated and identified as tricine, jaceosidine, eupafolin, chrysoeriol, diosmetin, homoeriodictyol, isorhamnetin, apigenin, eriodictyol, luteolin, luteolin 7-glucoside, kaempferol 3-glucoside, kaempferol 7-glucoside, kaempferol 3-rhamnoside, kaempferol 3-rutinoside, quercetin 3-glucoside, quercetin 3-galactoside, quercetrin, rutin, and vitexin. The most abundant compounds were eriodictyol and luteolin. The estrogenic activity of all flavonoids was assayed by employing a reconstituted estrogen transcription unit in Saccharomyces cerevisiae transformed with both a human estrogen receptor expression plasmid and a reporter plasmid. Two flavonoids, eriodictyol and apigenin, were able to induce the transcription of the reporter gene in transgenic yeast. The transcriptional activity increased proportionally with increased amounts of purified eriodictyol or apigenin added to the yeast cells.
Databáze:	OpenAIRE
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