Study of Ischemia Modified Albumin as New Potential Diagnostic Biomarker In Acute Myocardial Infarction
| Autor: | Dhananjay V. Andure, Abhijit P. Pathak, M. P. Bankar, Ramchandra K. Padalkar, Sangita M. Patil |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic business.industry Case-control study Albumin Gold standard (test) Creatine Chest pain medicine.disease chemistry.chemical_compound chemistry Internal medicine Troponin I Cardiology Medicine cardiovascular diseases Myocardial infarction medicine.symptom business |
| Zdroj: | VIMS Health Science Journal. 7:41-46 |
| ISSN: | 2454-1982 2348-523X |
| Popis: | Background: Because of the varied presentation and associated high mortality the identification of patients with acute myocardial infarction is very critical for the patient management and has a bearing on the prognosis. Only about 22% patients admitted to cardiac care centers with chest pain having truly myocardial infarction. Aim: The goal of present study was to assess diagnostic value of serum ischemia modified albumin and compare it with sensitive cardiac troponin I and Creatine Kinase-MB in acute myocardial infarction. Methods: A diagnostic case control study was conducted on 102 patients presenting to the Emergency Department within 6 hrs of acute chest pain and 115 healthy age and sex matched volunteers formed the control group. Serum ischemia modified albumin level was estimated by albumin cobalt binding test using digital spectrophotometer, while troponin I was measured by immunofluroscence assay and creatine Kinase-MB was determined by immunoinhibition method. The sensitivity and specificity of ischemia modified albumin, troponin I and creatine kinase-MB for detection of acute myocardial infarction were analyzed. The results of ischemia modified albumin, troponin I and creatine kinase-MB alone and in combination were correlated. Results: Ischemia modified albumin (p |
| Databáze: | OpenAIRE |
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