A novel synthesis of chromone based unnatural $$\upalpha $$ α -amino acid derivatives
| Autor: | Satyanarayana Yennam, Muralidaran Kaliyaperumala, Manoranjan Behera, Ramakrishna Gudipati, Anindita Chatterjee, Venu Kandula |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Schiff base 010405 organic chemistry Stereochemistry General Chemistry Alkylation 010402 general chemistry 01 natural sciences 0104 chemical sciences Amino acid Chiral column chromatography chemistry.chemical_compound Propanoic acid chemistry Chromone Moiety Phenyl group |
| Zdroj: | Journal of Chemical Sciences. 129:1233-1245 |
| ISSN: | 0973-7103 0974-3626 |
| Popis: | An efficient method for the preparation of chromone based $$\upalpha $$ -amino acid derivatives by alkylation of glycinate schiff base with 3-bromomethyl chromone as well as 2-bromomethyl chromone has been described. Using this method, 2-amino-3-(4-oxo-2-chromenyl)propanoic acid and 2-amino-3-(4-oxo-3-chromenyl)propanoic acid, two novel chromone-amino acid conjugates have been prepared. Furthermore, the separation of chromone amino acid enantiomers by chiral column chromatography was accomplished. Synopsis: An efficient method for the preparation of chromone based $$\upalpha $$ -amino acid derivatives by alkylation of glycinate schiff base with 3-bromomethyl chromone as well as 2-bromomethyl chromone has been described. These conjugates can be considered as analogues of phenyl alanine where phenyl group has been replaced by chromone moiety. |
| Databáze: | OpenAIRE |
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