| Popis: |
In addition to Langerhans cells, the epidermis of all strains of normal mice harbors another population of bone marrow-derived dendritic cells. Because of their abundant expression of surface-bound Thy-1 antigens these CD45+, asialo-GM1+, la-, CD4-, CD5-, CD8- cells have originally been referred to as Thy-1+ dendritic epidermal cells (Thy-1+ DEC; Romani et al., 1985). The original assumption that Thy-1+ DEC belong to the T cell lineage was proven conclusively with the subsequent demonstration that the overwhelming majority of Thy-1+ DEC in normal adult epidermis expressed CD3-associated TCR γ/δ heterodimers (Stingl et al., 1987; Steiner et al., 1988). In view of this finding, we have proposed that Thy-1+ DEC should be renamed dendritic epidermal T cells (DETC; Steiner et al., 1988). |
