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This chapter examines the state of the art and the application of agitator bead mills for cell disruption. Commercial high-speed bead mills have originally been constructed for the comminution of fine solids in thick, viscous suspensions down to the submicrometer range. The agitator has to accomplish the energy transfer to the grinding beads; therefore, its design is highly important for the grinding efficiency. Disk agitators are characterized by a number of disks fitted to the central shaft in a centric or eccentric position. Most of the mill manufacturers are producing both vertical and horizontal mills, in part with identical design of the grinding chamber and agitator. The task of a media separator is to retain the grinding beads in the chamber during operation while allowing continuous passage of slurry through the exit. The task of a high-speed agitator bead mill is to comminute particles or to disrupt microorganisms in a liquid suspension. |
