Autologous Retinal Transplantation for Primary and Refractory Macular Holes and Macular Hole Retinal Detachments
| Autor: | Ogugua Ndubuisi Okonkwo, Ninel Z. Gregori, Mitsunori Yamada, Nicole Koulisis, Shunji Kusaka, Jay Chhablani, Keiko Yamada, Takatoshi Maeno, Alberto La Mantia, Odette M. Houghton, Stavros N. Moysidis, Mohamed M Mahgoub, Virgilio Morales-Canton, Marcin Stopa, Steve Charles, Hisham Hassaan, Sergio Rojas, Hany S. Hamza, Tarek S Hassan, An Lun Wu, Xhevat Lumi, Ahmed M. Habib, Carmelina Gordon, Sean D. Adrean, Sherif Nabil Embabi, Izabela Rogalinska, Barbara Parolini, Mohamed Nowara, Flavio A. Rezende, Naren Chetty, Tamer H. Mahmoud, Chi Chun Lai, Samir Mohamed El Baha, David H. W. Steel, Kazuaki Kadonosono, Javier Cisneros Cortes |
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| Rok vydání: | 2021 |
| Předmět: |
Pars plana
medicine.medical_specialty Visual acuity genetic structures business.industry medicine.medical_treatment Retinal detachment Vitrectomy Retinal medicine.disease eye diseases Transplantation Ophthalmology chemistry.chemical_compound medicine.anatomical_structure chemistry medicine medicine.symptom business External limiting membrane Macular hole |
| Zdroj: | Ophthalmology. 128:672-685 |
| ISSN: | 0161-6420 |
| Popis: | Purpose To report the anatomic and functional outcomes of autologous retinal transplantation (ART). Design Multicenter, retrospective, interventional, consecutive case series. Participants One hundred thirty eyes of 130 patients undergoing ART for the repair of primary and refractory macular holes (MHs), as well as combined MH-rhegmatogenous retinal detachment (MH-RRD), between January 2017 and December 2019. Methods All patients underwent pars plana vitrectomy and ART, with surgeon modification of intraoperative variables. A large array of preoperative, intraoperative, and postoperative data was collected. Two masked reviewers graded OCT images. Multivariate statistical analysis and subgroup analysis were performed. Main Outcome Measures Macular hole closure rate, visual acuity (VA), external limiting membrane and ellipsoid zone (EZ) band integrity, and alignment of neurosensory layers (ANL) on OCT. Results One hundred thirty ART surgeries were performed by 33 vitreoretinal surgeons worldwide. Patient demographics were: mean age of 63 ± 6.3 years, 58% female, 41% White, 23% Black, 19% Asian, and 17% Latino. Preoperative VA was 1.37 ± 0.12 logarithm of the minimum angle of resolution (logMAR; Snellen equivalent, approximately 20/500), which improved significantly to 1.05 ± 0.09 logMAR (Snellen equivalent, approximately 20/225; P Conclusions In this global experience, patients undergoing ART for large primary and refractory MHs and MH-RRDs achieved good anatomic and functional outcomes, with low complication rates despite complex surgical pathologic features. |
| Databáze: | OpenAIRE |
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