Microemulsions as topical drug delivery vehicles: in-vitro transdermal studies of a model hydrophilic drug

Autor:	D. W. Osborne, Anthony J. I. Ward, K. J. O'neill
Rok vydání:	1991
Předmět:	Pharmacology Octanol Chromatography Glucose transporter Pharmaceutical Science Excipient Absorption (skin) Dosage form chemistry.chemical_compound chemistry medicine Microemulsion Pharmaceutical Vehicles Transdermal medicine.drug
Zdroj:	Journal of Pharmacy and Pharmacology. 43:451-454
ISSN:	2042-7158 0022-3573
DOI:	10.1111/j.2042-7158.1991.tb03511.x
Popis:	Microemulsions with a 58:42 weight ratio of dioctyl sodium sulphosuccinate: octanol and containing 15, 35, and 68% water have been tested for their ability to transport glucose across human cadaver skin. A flow-through multisample skin diffusion cell showed that both the 35 and 68% water microemulsions caused enhanced (approximately 30-fold) transport of glucose. No transport was discernible for the 15% water microemulsion. Differences in percutaneous glucose transport were shown to parallel differences in the diffusion of water within the microemulsion vehicles before application to the skin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::799ff5147b087cce1fb926754567409a https://doi.org/10.1111/j.2042-7158.1991.tb03511.x Zobrazit plný text záznamu Plný text