Allelic variants of DYX1C1 are not associated with dyslexia in India
| Autor: | Rajasekhara Reddy Ravuri, U Kiran, Pushpa Saviour, Satish Kumar, Vadlamudi Raghavendra Rao, Nallur B. Ramachandra |
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| Rok vydání: | 2008 |
| Předmět: |
Genetics
Candidate gene education.field_of_study Population Dyslexia Single-nucleotide polymorphism Biology medicine.disease behavioral disciplines and activities nervous system diseases Exon mental disorders medicine Learning to read Allele education Gene psychological phenomena and processes Genetics (clinical) |
| Zdroj: | Indian Journal of Human Genetics. 14:99 |
| ISSN: | 0971-6866 |
| DOI: | 10.4103/0971-6866.45002 |
| Popis: | Dyslexia is a hereditary neurological disorder that manifests as an unexpected difficulty in learning to read despite adequate intelligence, education, and normal senses. The prevalence of dyslexia ranges from 3 to 15% of the school aged children. Many genetic studies indicated that loci on 6p21.3, 15q15-21, and 18p11.2 have been identified as promising candidate gene regions for dyslexia. Recently, it has been suggested that allelic variants of gene, DYX1C1 influence dyslexia. In the present study, exon 2 and 10 of DYX1C1 has been analyzed to verify whether these single nucleotide polymorphisms (SNPs) influence dyslexia, in our population. Our study identified 4 SNPs however, none of these SNPS were found to be significantly associated with dyslexia suggesting DYX1C1 allelic variants are not associated with dyslexia. |
| Databáze: | OpenAIRE |
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