Effect of cytoreductive surgery and HIPEC on survival in comparison to palliative chemotherapy for biliary carcinoma with peritoneal metastasis: A multi-institutional cohort from PSOGI and BIG RENAPE groups
| Autor: | Laurent Villeneuve, Yutaka Yonemura, Marc Pocard, François Quenet, Beate Rau, David L. Bartlett, Frederic Mercier, Edward A. Levine, Iris Amblard, David L. Morris, Pompiliu Piso, A.A.K. Tentes, Gérard Lorimier, Olivier Glehen, D. Delroeux, Dario Baratti, Eduardo Hiroshi Akaishi, Jean-Jacques Tuech, Guillaume Passot |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Peritoneal metastasis Chemotherapy Poor prognosis business.industry medicine.medical_treatment Palliative chemotherapy 030230 surgery Biliary carcinoma 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Cohort medicine Cytoreductive surgery business |
| Zdroj: | Journal of Clinical Oncology. 36:418-418 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2018.36.4_suppl.418 |
| Popis: | 418 Background: Peritoneal metastasis from biliary carcinoma (PMC) is associated with poor prognosis when treated with chemotherapy. The objective was to evaluate the impact on survival of cytoreduction surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), and compare with conventional palliative chemotherapy for patients with PMC. Methods: A prospective multicenter international database was retrospectively searched to identify all patients with PMC treated with a potentially curative CRS/HIPEC (CRS/HIPEC group). The overall survival (OS) was compared to patients with PMC treated with palliative chemotherapy (systemic chemotherapy group). Survival was analyzed using Kaplan-Meier method and compared with Log-Rank test. Results: Between 1995 and 2015, 34 patients were included in the surgical group, and compared to 21 in the medical group. In the surgical group, median peritoneal cancer index was 9 (range 3-26), macroscopically complete resection was obtained for 25 patients (73%). There was more gallbladder localization in the surgical group compared to the medical group (35% vs. 18%, p= 0.001). Median OS was 21.4 and 9.3 months for surgical and medical group, respectively (p =0.007). Three-year overall survival was 30% and 10% for surgical and medical group, respectively. Conclusions: Treatment with CRS and HIPEC for cholangiocarcinoma with peritoneal metastasis is feasible and may provide survival benefit when compared to palliative chemotherapy. |
| Databáze: | OpenAIRE |
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