Epidermal growth factor, tumor necrosis factor alpha, and thioredoxin in cerebral tissue following cerebral ischemia / Serebral iskemi sonrası beyin dokusunda epidermal büyüme faktörü, tümör nekrozis faktör alfa ve tiyoredoksin

Autor:	Nedret Kiliç, Hatice Ferhan Komurcu, Serdar Kahraman, Melike Erol Demirbilek
Rok vydání:	2015
Předmět:	medicine.medical_specialty Pathology business.industry Biochemistry (medical) Clinical Biochemistry Ischemia medicine.disease Biochemistry Endocrinology Epidermal growth factor Internal medicine medicine Tumor necrosis factor alpha Cerebral tissue Thioredoxin business Molecular Biology
Zdroj:	Turkish Journal of Biochemistry. 40
ISSN:	1303-829X 0250-4685
Popis:	Objective: In this study, the changes in the levels of the epidermal growth factor (EGF), tumor necrosis factor alpha (TNF-α), and thioredoxine (TRX) in the cerebral tissue of rats following the cerebral ischemia model were investigated.Methods: The left middle cerebral artery occlusion (MCAO) was done in 27 out of 48 rats recruited into the study for obtaining focal cerebral ischemia model (MCAO group). Twenty-one rats underwent a sham operation; the middle cerebral artery was exposed but not occluded (Sham group). EGF, TNF-α, and TRX levels were studied in the operated left and contralateral hemispheres at the 16Results: EGF levels at 96Conclusion: The results suggested that cerebral ischemia following MCAO might affect EGF, TNF-α and TRX levels in both ischemic and contralateral hemispheres in cerebral tissue; and this effect may change by the time passed after MCAO.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::79936e62e002234b0a7b8b5b21f25bda https://doi.org/10.1515/tjb-2015-0043 Zobrazit plný text záznamu