Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management
| Autor: | Salomon A Stavchansky, Phillip D. Bowman, Ashish Rastogi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Drug
medicine.medical_specialty business.industry Local anesthetic medicine.drug_class media_common.quotation_subject Chronic pain Pain management medicine.disease Controlled release Surgery chemistry.chemical_compound chemistry Prolonged release Anesthesia Drug delivery medicine business Butamben media_common |
| Zdroj: | Pharmacology & Pharmacy. :291-294 |
| ISSN: | 2157-9431 2157-9423 |
| DOI: | 10.4236/pp.2012.33038 |
| Popis: | Continuous delivery of local anesthetics might be useful for management of localized and chronic pain. Controlled release injectable anesthetics have been developed but they can deliver the drug for only few days and the release is not zero-order. A drug delivery system (DDS) consisting of a perforated reservoir for drug containment and release and its potential for management of chronic pain is described. Proof of principle is detailed for long-term zero order delivery of butamben. In this study, the DDS was a polyimide tube with a 0.20 mm hole and butamben release was evaluated in vitro. It is envisioned that the DDS could be implanted in proximity to a nerve, enervating the pain source, for long-term control of chronic pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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