Aminolysis of 6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methyl-2-(nitroamino)pyrimidin-4(3H)-one

Autor:	L. L. Brunilina, E. A. Ruchko, A. A. Vernigora, Vadim V. Kachala, Ivan A. Novakov, D. S. Sheikin, I. A. Kirillov, A. S. Yablokov, A. S. Mkrtchyan, M. B. Navrotskii
Rok vydání:	2017
Předmět:	Steric effects chemistry.chemical_classification Base (chemistry) 010405 organic chemistry Chemistry Organic Chemistry Dielectric permittivity 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis 010404 medicinal & biomolecular chemistry Aminolysis Reagent Amine gas treating
Zdroj:	Russian Journal of Organic Chemistry. 53:1844-1850
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428017120107
Popis:	The aminolysis of 6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methyl-2-(nitroamino)pyrimidin-4(3H)-one with various amines in butan-1-ol and under solvent-free conditions is successful when the amino group in the reagent is sterically unshielded and the reaction medium is characterized by a high dielectric permittivity. Reactions of the title compound with sterically shielded amines are accompanied by alcoholysis where the amine acts as a base catalyst.
Databáze:	OpenAIRE
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