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Background:- Microalbuminuria is one of the early indicators of sepsis. It is caused by diffused endothelial dysfunction in critically ill septic patients. The degree of microalbuminuria corresponds with the intensity of the inflammatory contempt. Purpose:- To investigate whether microalbuminuria has a prognostic value in surgical sepsis or not, with particular regard to its role in anticipating illness intensity, clinical course and mortality. Methods:- The study was applied in the critical care unit, Sayed Galal hospital, Faculty of medicine, Al-Azhar university. A sum of 80 patients were included in a prospective, non-interventional study following major abdominal surgery, and divided into two groups each group containing 40 patients. Albumin/Creatinine ratio (ACR, mg/g) was measured in urinary samples collected preoperatively (tp), upon ICU admission (t0), after 6 hours (t6) and at 24 hours (t24). Acute physiology and chronic health evaluation II (APACHE II) score was calculated 24, 48 and 72 hours, and Sequential Organ Failure assessment (SOFA) score was calculated daily for 3 days. Clinical outcome (length of ICU stay), and final outcome (survival or mortality rates) were recorded and documented for all patients. Results:- There was statistically significant difference between groups according to ACR t0 to t24 specially at t6 which was highly significant in group II in relation to group I with p-value |
