Transition-Metal-Free N-(o-Halo)arylation of Sulfoximines/Sulfonimidamides

Autor:	Ganesh Chandra Nandi, V. R. Padma Priya, C. P. Irfana Jesin
Rok vydání:	2022
Předmět:	Organic Chemistry
Zdroj:	Synlett. 34:678-682
ISSN:	1437-2096 0936-5214
DOI:	10.1055/a-1921-0875
Popis:	A transition-metal-free novel route to access N-(o-halo)arylsulfoximines/sulfonimidamides is achieved by the reaction of sulfoximine/sulfonimidamide, aryne precursor, and CCl4/CBr4 in the presence of KF/18-crown-6. The in situ generated benzyne intermediate (from silyl aryl triflate) reacts with the nucleophile (sulfoximine/sulfonimidamide) and halide source (CCl4/CBr4) to yield the product in moderate to good yield. The protocol exhibits broad substrate scope. The regioisomers formed from the unsymmetric aryne precursor were separated effectively via column chromatography.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7978c52fbe38b0591ddafb89ea1413b0 https://doi.org/10.1055/a-1921-0875 Zobrazit plný text záznamu