Immunoexpression of keratins in the calcifying cystic odontogenic tumor epithelium
| Autor: | Ana Maria Pires Soubhia, Marcelo Macedo Crivelini, Gilberto Aparecido Coclete, Renata Callestini Felipini |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Cancer Research Pathology medicine.medical_specialty integumentary system biology Odontogenic tumor Stratified squamous epithelium Ghost cell Vimentin macromolecular substances medicine.disease Epithelium Pathology and Forensic Medicine medicine.anatomical_structure Otorhinolaryngology chemistry Laminin Keratin medicine biology.protein Periodontics Immunohistochemistry Oral Surgery |
| Zdroj: | Journal of Oral Pathology & Medicine. 38:393-396 |
| ISSN: | 0904-2512 |
| Popis: | Ameloblastomatous epithelium containing clusters of ghost cells is the typical histopathology of calcifying cystic odontogenic tumor (CCOT). This paper aimed to assess keratins AE1-AE3, K7, K10/13, K14, K18, K19, vimentin, laminin, and collagen IV in 08 CCOTs to discuss their histopathogenesis. Similarity to the immunoprofile of the stratified squamous epithelium was seen in the with the basal layer expressing K14 and the upper cells expressing K10/13. When compared to the immunoprofile of the normal odontogenic epithelium, of odontogenic tumor epithelia and of the ghost cells described in the literature, it was possible to suggest that the CCOT epithelium differentiates towards squamous type. |
| Databáze: | OpenAIRE |
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