P117 Patient perceptions about causes of flare in IBD: results from the baseline dataset of the PREdiCCt study

Autor:	Lauranne A A P Derikx, Charlie W. Lees, Nikolas Plevris, L Derr, L Williams, L Murdoch, S Siakavellas, Philip Jenkinson, G R Jones, N Constantine-Cooke, K Covil, L Laura
Rok vydání:	2021
Předmět:	medicine.medical_specialty Surrogate endpoint business.industry Gastroenterology Dietary factors General Medicine law.invention Patient perceptions Patient Self-Report law Internal medicine Disease remission medicine Baseline (configuration management) business Flare
Zdroj:	Journal of Crohn's and Colitis. 15:S209-S209
ISSN:	1876-4479 1873-9946
DOI:	10.1093/ecco-jcc/jjab076.244
Popis:	Background Patient reported outcomes are important endpoints in IBD management, but patient perceptions of the causes of disease flare are unknown and thus may reveal novel areas for future study. Methods The PREdiCCt study (https://www.predicct.co.uk) is the largest prospective study of the causes of IBD flare. 2629 patients in clinical remission were recruited from 48 UK sites and followed for 2 years with detailed assessment of environmental and dietary factors via monthly questionnaires. 1946 (74%) patients completed the baseline questionnaires. We present here the results of the baseline questionnaire analysis of patient perceptions of disease flare, derived from a list of 17 putative causes from the literature and their own experience via free text input. Results In total 1,946 IBD patients [male=852, CD=1000; UC/IBDU=946, age 45.8±15.5 (mean±SD in years)] gave their opinion about factors initiating a flare. The commonest causes reported were stress (n=1359, 69.8%), dietary changes (n=911, 46.8%), alcohol use (n=385, 19.8%), sleep disturbances (n=331, 17%) and that their medication stopped working (n=308, 15.8%) (Figure 1). CD participants were more likely to identify dietary changes (50% vs 43%, p Conclusion Stress, dietary changes and alcohol use were identified as the main causes of flare by patients with dietary changes more frequently reported in CD (especially those with small bowel involvement). The impact of environmental and dietary factors in the development of flare is being further investigated with ongoing longitudinal data collection in the PREdiCCt Study.
Databáze:	OpenAIRE
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