Effects of Endotoxemia on Thrombopoiesis in Men

Autor:	Claudia C. Folman, Hans-Georg Eichler, Simon Panzer, Thomas Pernerstorfer, Bernd Jilma, Albert E. G. Kr. von dem Borne, Petra Stohlawetz
Rok vydání:	1999
Předmět:	Aspirin medicine.medical_specialty Lipopolysaccharide business.industry Inflammation Hematology Cell aggregation Haematopoiesis chemistry.chemical_compound Endocrinology chemistry Internal medicine Immunology medicine Platelet Thrombopoiesis medicine.symptom business Thrombopoietin medicine.drug
Zdroj:	Thrombosis and Haemostasis. 81:613-617
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0037-1614534
Popis:	Summary Background. Febrile conditions are often associated with increased platelet turnover and refractoriness to platelet transfusions, although several pyrogenic cytokines enhance thrombopoiesis. This study aimed to characterize the effects of experimental human endotoxemia on platelet turnover and thrombopoiesis. Methods. Endotoxin (4 ng/kg) was infused into 30 healthy men to study the regulation of thrombopoiesis in systemic human inflammation. Platelet counts, plasma thrombopoietin (TPO) and glycocalicin levels, and reticulated platelets (RP) were measured to evaluate the effect of acute endotoxemia on thrombopoiesis. Ten subjects received pretreatment with 1000 mg aspirin po. to evaluate possible effects of aspirin on platelet turnover, and ten subjects received paracetamol to control for effects of anti-pyresis. Results. Platelet counts dropped by about 15% (p 0.05). The number of circulating platelet-neutrophil aggregates increased more than 100% at 6 h (p
Databáze:	OpenAIRE
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